interleukin-32; IL-32; natural killer cells protein 4; tumor necrosis factor alpha-inducing factor (IL32 NK4 TAIF)

Function

• cytokine that may play a role in the innate immune response & the adaptive immune response
• induces various cytokines such as TNF-alpha & IL8
• activates typical cytokine signal pathways of NF-kappa-B & p38MAPK

Compartment

secreted

Alternative splicing

named isoforms=4

Expression

• selectively expressed in lymphocytes
• expression is more prominent in immune cells than in non-immune cells
• expression increased after activation of T-cells by mitogens or activation of NK cells by IL2

More general terms

• interleukin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9235
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9235
• OMIM: https://mirror.omim.org/entry/606001
• UniProt: http://www.uniprot.org/uniprot/P24001.html