metaphase chromosome protein 1; metaphase chromosome protein 30 (HSMCR30, MCP1, MCP30)

Function

• required during early stages of DNA replication such as the G1/S transition phase & early S phase
• phosphorylated
• associates with replication factors required for the initiation of DNA replication & binds to the initiation sites in loci that replicate early in S-phase
• the 31 kD form interacts with CDC6, ORC2, ORC4, MCM2, MCM3, MCM7, CDC45 & PCNA
• both the 31 kD & 33 kD forms interact with HIST1H1A, HIST1H1B & HIST1H1C

Compartment

• nucleus, chromosome
• associated with condensed chromosomes throughout mitosis
• during interphase, shows a speckle distribution in the nucleus, excluding the nucleolus

Notes

• 2 forms: 33 kD, & 31 kD are probably produced by initiation at Met-1 & Met-24 respectively
• uncertain whether Met-1 or Met-24 is the initiator
• product of a dubious CDS prediction
• not possible to identify the locus for this potential gene on the reference genome & similarity searches suggest it might not be of human origin evidences presented in refs [2=4]

• - UniProt entry deleted

More general terms

• nuclear protein