CDC45-related protein; cell division cycle 45 S. cerevisiae homolog-like; cell division control protein 45 homolog; PORC-PI-1 (CDC45, CDC45L, CDC45L2, UNQ374/PRO710)

Function

• required for initiation of chromosomal DNA replication
• associated with ORC2

Structure

belongs to the CDC45 family

Compartment

cytoplasm. nucleus

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest levels are found in adult testis & thymus & in fetal liver
• transcript peaks at G1-S phase transition, but total protein remains constant throughout the cell cycle
• expressed in multiple tissues during embryogenesis, including neural crest-derived structures

More general terms

• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8318
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8318
• OMIM: https://mirror.omim.org/entry/603465
• UniProt: http://www.uniprot.org/uniprot/O75419.html