automated closed-loop insulin delivery; automated insulin dosing controller; automated glycemic controller device; artificial pancreas

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Introduction

Also see bionic pancreas.

Indications

Mechanism of action

Notes

  • children age 2-6 years with an artifical pancreas achieve 3 hours more/day in their target glucose range[11]

More general terms

Additional terms

References

  1. ↑ Jump up to: 1.0 1.1 Hovorka R et al. Overnight closed loop insulin delivery (artificial pancreas) in adults with type 1 diabetes: Crossover randomised controlled studies. BMJ 2011 Apr 14; 342:d1855 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21493665
  2. ↑ Jump up to: 2.0 2.1 Haidar A et al Comparison of dual-hormone artificial pancreas, single-hormone artificial pancreas, and conventional insulin pump therapy for glycaemic control in patients with type 1 diabetes: an open- label randomised controlled crossover trial. The Lancet Diabetes & Endocrinology, 27 November 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25434967 <Internet> http://www.thelancet.com/journals/landia/article/PIIS2213-8587%2814%2970226-8/fulltext
    Russell SJ When you come to a fork in the road, take it! The Lancet Diabetes & Endocrinology, 27 November 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25434966 <Internet> http://www.thelancet.com/journals/landia/article/PIIS2213-8587%2814%2970195-0/fulltext
  3. ↑ Thabit H et al. Home use of an artificial beta cell in type 1 diabetes. N Engl J Med 2015 Sep 17 PMID: https://www.ncbi.nlm.nih.gov/pubmed/26379095
  4. ↑ Jump up to: 4.0 4.1 Tucker ME FDA Approves First 'Artificial Pancreas' for Type 1 Diabetes. Medscape. Sep 28, 2016. http://www.medscape.com/viewarticle/869400
    FDA News Release. September 28, 2016 FDA approves first automated insulin delivery device for type 1 diabetes. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm522974.htm
  5. ↑ Jump up to: 5.0 5.1 Thabit H, Hartnell S, Allen JM et al Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial. Lancet Diabetes & Endocrinology Nov 8 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27836235 Free Article <Internet> http://thelancet.com/journals/landia/article/PIIS2213-8587(16)30280-7/fulltext
    Rayman G Closer to closing the loop on inpatient glycaemia. Lancet Diabetes & Endocrinology Nov 8 2016 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/27836233 Free Article <Internet> http://thelancet.com/journals/landia/article/PIIS2213-8587(16)30327-8/fulltext
  6. ↑ Jump up to: 6.0 6.1 6.2 Bekiari E, Kitsios K, Thabit H et al Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis. BMJ 2018;361:k1310 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29669716 https://www.bmj.com/content/361/bmj.k1310
    Waugh N, Adler A, Craigie I, Omer T. Closed loop systems in type 1 diabetes BMJ 2018;361:k1613 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29669729 https://www.bmj.com/content/361/bmj.k1613
  7. ↑ Jump up to: 7.0 7.1 Bally L, Thabit H, Hartnell S et al. Closed-loop insulin delivery for glycemic control in noncritical care. N Engl J Med 2018 Jun 25; PMID: https://www.ncbi.nlm.nih.gov/pubmed/29940126 Free Article
  8. ↑ Jump up to: 8.0 8.1 Tauschmann M, Thabit H, Bally L et al Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial. Lancet. 2018 Oct 13;392(10155):1321-1329. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30292578 Free PMC Article
    Galderisi A, Sherr JL. Enlarging the loop: closed-loop insulin delivery for type 1 diabetes. Lancet. 2018 Oct 13;392(10155):1282-1284. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30292579 Free full text
  9. ↑ FDA News Release. Dec 13, 2019 FDA authorizes first interoperable, automated insulin dosing controller designed to allow more choices for patients looking to customize their individual diabetes management device system. https://www.fda.gov/news-events/press-announcements/fda-authorizes-first-interoperable-automated-insulin-dosing-controller-designed-allow-more-choices
  10. ↑ Jump up to: 10.0 10.1 Monaco K FDA OK's Trijardy XR; Dual Hormone Artificial Pancreas - News and commentary from the endocrinology world MedPage Today January 31, 2020 https://www.medpagetoday.com/endocrinology/generalendocrinology/84653
  11. ↑ Jump up to: 11.0 11.1 Wadwa RP, Reed ZW, Buckingham BA et al Trial of Hybrid Closed-Loop Control in Young Children with Type 1 Diabetes. N Engl J Med 2023; 388:991-1001. March 16. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36920756 Clinical Trial. https://www.nejm.org/doi/full/10.1056/NEJMoa2210834
  12. ↑ Jump up to: 12.0 12.1 Monaco K FDA Clears First Automated Insulin-Delivery Tech for Type 2 Diabetes. SmartAdjust technology is used in Insulet's Omnipod 5 Automated Insulin Delivery System. MedPage Today August 27, 2024 https://www.medpagetoday.com/endocrinology/diabetes/111676
    Tucker ME FDA Clears the Omnipod 5 System for Type 2 Diabetes. Medscape. August 26, 2024 https://www.medscape.com/viewarticle/fda-clears-omnipod-5-system-type-2-diabetes-2024a1000fld
  13. ↑ Jump up to: 13.0 13.1 Di Molfetta S, Di Gioia L, Caruso I et al Efficacy and Safety of Different Hybrid Closed Loop Systems for Automated Insulin Delivery in People With Type 1 Diabetes: A Systematic Review and Network Meta-Analysis. Diabetes Metab Res Rev. 2024 Sep;40(6):e3842. PMID: https://www.ncbi.nlm.nih.gov/pubmed/39298688 https://onlinelibrary.wiley.com/doi/10.1002/dmrr.3842
  14. ↑ Jump up to: 14.0 14.1 Kudva YC, Raghinaru D, Lum JW, et al. A Randomized Trial of Automated Insulin Delivery in Type 2 Diabetes. N Engl J Med. 2025 Mar 19. PMID: https://www.ncbi.nlm.nih.gov/pubmed/40105270 https://www.nejm.org/doi/10.1056/NEJMoa2415948
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