bionic pancreas
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Introduction
Investigational, wearable, automated, bihormonal device
Also see automated closed-loop insulin delivery
Indications
Clinical significance
- better glycemic control than insulin pump
- lowers mean plasma glucose & duration of hypoglycemia[2]
Procedure
- continuous glucose monitor
- delivers glucagon & insulin, based on an adaptive algorithm
Notes
- iLet bionic pancreas, an automated system that requires patients to input only body weight & broadly estimated carbohydrate content of upcoming meals (usual, more or less)
More general terms
Additional terms
References
- ↑ Russell SJ et al Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes. N Engl J Med. June 15, 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24931572 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1314474
- ↑ 2.0 2.1 El-Khatib FH et al. Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: A multicentre randomised crossover trial. Lancet 2016 Dec 19; PMID: https://www.ncbi.nlm.nih.gov/pubmed/28007348
Murphy HR, Stewart ZA. Automated insulin delivery: What's new, needed, and next? Lancet 2016 Dec 19; PMID: https://www.ncbi.nlm.nih.gov/pubmed/28007347 - ↑ Bionic Pancreas Research Group. Multicenter, randomized trial of a bionic pancreas in type 1 diabetes. N Engl J Med 2022 Sep 29; 387:1161. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36170500 https://www.nejm.org/doi/10.1056/NEJMoa2205225
Sherr J. Seeking simpler solutions with diabetes technology. N Engl J Med 2022 Sep 29; 387:1228. PMID: https://www.ncbi.nlm.nih.gov/pubmed/36170505 https://www.nejm.org/doi/10.1056/NEJMe2210686