UV-damaged DNA-binding protein complex (UV-DDB complex)

Function

• may recognize UV-induced DNA damage & recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair
• preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites & short mismatches
• interacts with monoubiquitinated histone H2A & binds to XPC via the DDB2 subunit

Structure

• subunits include DDB1 & DDB2

More general terms

• molecular complex