cystatin C in serum/plasma
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Indications
- assessment of renal function, renal insufficiency (GFR)
Clinical significance
- levels affected by thyroid function, diabetes mellitus, inflammation, glucocorticoids, malignancy, HIV1 infection[5]
- useful in elderly & patients with cirrhosis[5]
- sensitive to small changes in GFR
- less sensitive than serum creatinine to changes in muscle mass[5]
- for some patients cystatin C-based measures of GFR may be more accurate than creatinine-based measures[8]
- cystatin C-based measures may have prognostic value
- adverse outcomes, including ESRD, cardiovacular events & mortality, are more common when cystatin C-based measurements of GFR are signficantly lower than creatinine-based measures[8]
Notes
More general terms
Additional terms
References
- ↑ Inker LA et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med 2012 Jul 5; 367:20. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22762323
Weir MR. Improving the estimating equation for GFR - A clinical perspective. N Engl J Med 2012 Jul 5; 367:75. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22762323 - ↑ Cystatin C Lab Tests Online: http://www.labtestsonline.org/understanding/analytes/cystatin_c/glance.html
- ↑ Cystatin C Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0095229.jsp
- ↑ 4.0 4.1 Schaeffner ES et al Two Novel Equations to Estimate Kidney Function in Persons Aged 70 Years or Older Ann Intern Med. 2 October 2012;157(7):471-481 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/23027318 <Internet> http://annals.org/article.aspx?articleid=1363512
- ↑ 5.0 5.1 5.2 5.3 Medical Knowledge Self Assessment Program (MKSAP) 17, 18, American College of Physicians, Philadelphia 2015, 2018
- ↑ Baxmann AC, Ahmed MS, Marques NC et al Influence of muscle mass and physical activity on serum and urinary creatinine and serum cystatin C. Clin J Am Soc Nephrol. 2008 Mar;3(2):348-54. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18235143 Free PMC Article
- ↑ Shlipak MG, Inker LA, Coresh J Serum Cystatin C for Estimation of GFR JAMA. Published online August 8, 2022 PMID: https://www.ncbi.nlm.nih.gov/pubmed/35939309 https://jamanetwork.com/journals/jama/fullarticle/2795292
- ↑ 8.0 8.1 8.2 Carrero JJ et al. Discordances between creatinine- and cystatin C-based estimated GFR and adverse clinical outcomes in routine clinical practice. Am J Kidney Dis 2023 Nov; 82:534. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37354936 Free article https://www.ajkd.org/article/S0272-6386(23)00691-1/fulltext
Pinsino A et al. The difference between cystatin C-and creatinine-based estimated GFR in heart failure with reduced ejection fraction: Insights from PARADIGM-HF. Am J Kidney Dis 2023 Nov; 82:521. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37086965 https://www.ajkd.org/article/S0272-6386(23)00609-1/fulltext
Grubb AO et al. Etiologic and diagnostic implications of morbidity and mortality associations when cystatin C-based estimated GFR is lower than creatinine-based estimated GFR. Am J Kidney Dis 2023 Nov; 82:509. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37737748 https://www.ajkd.org/article/S0272-6386(23)00778-3/fulltext