cystatin 3 (cystatin-C, CST3)

Function

• inhibitor of cysteine proteinases
• must inhibit protease that hydrolyzes gamma-trace

Structure

• homodimer
• belongs to the cystatin family

Compartment

secreted

Expression

• found in various body fluids, including CSF & plasma
• expressed in highest levels in epididymis, vas deferens, brain, thymus, & ovary
• lowest levels in the submandibular gland

Pathology

• defects in CST3 are a cause of amyloidosis type 6
• potential CSF marker for diagnosis of Creutzfeldt-Jakob disease

Laboratory

• cystatin C in serum/plasma

More general terms

• cystatin

Additional terms

• cystatin C in serum/plasma

Database

• UniProt: http://www.uniprot.org/uniprot/P01034.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1471
• OMIM: https://mirror.omim.org/entry/105150
• OMIM: https://mirror.omim.org/entry/604312
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1471