cystatin 3 (cystatin-C, CST3)
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Function
- inhibitor of cysteine proteinases
- must inhibit protease that hydrolyzes gamma-trace
Structure
- homodimer
- belongs to the cystatin family
Compartment
Expression
- found in various body fluids, including CSF & plasma
- expressed in highest levels in epididymis, vas deferens, brain, thymus, & ovary
- lowest levels in the submandibular gland
- tumor cells secreted cystatin-C
Pathology
- defects in cystsatin-C (CST3) are a cause of amyloidosis type 6
- potential CSF marker for diagnosis of Creutzfeldt-Jakob disease
- cancer attenuates amyloid pathology in Alzheimer's disease via cystatin-c activation of TREM2[3]
Laboratory
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P01034.html
- ↑ OMIM https://mirror.omim.org/entry/105150
- ↑ 3.0 3.1 Ledford H Cancer might protect against Alzheimer's - this protein helps explain why. Nature News. Jan 22, 2026 https://www.nature.com/articles/d41586-026-00222-7
Li X, Tang X, Zeng J et al Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystatin-c activation of TREM2. Cell. Jan 22, 2026 Not yet indexed in PubMed https://www.cell.com/cell/abstract/S0092-8674(25)01433-3