venous thromboembolism associated with pregnancy

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Etiology

(risk factors)

* odds ratio in parenthesis

Pathology

Genetics

* antepartum & postpartum absolute risks in parenthesis

* heterozygous factor V Leiden & prothrombin G20210A mutations with risks < 3%[10]

Laboratory

Radiology

* if doppler ultrasound shows DVT, treatment for pulmonary embolism is the same[11]

Complications

Management

More general terms

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Medical Knowledge Self Assessment Program (MKSAP) 15, 16, 17, 18. American College of Physicians, Philadelphia 2009, 2012, 2015, 2018.
  2. 2.0 2.1 2.2 2.3 ACOG Committee on Practice Bulletins-Obstetrics. Practice Bulletin No. 123: Thromboembolism in Pregnancy. Obstet Gynecol 2011 Sep; 118:718. PMID: https://www.ncbi.nlm.nih.gov/pubmed/21860313
  3. Chunilal SD, Bates SM. Venous thromboembolism in pregnancy: diagnosis, management and prevention. Thromb Haemost. 2009 Mar;101(3):428-38. PMID: https://www.ncbi.nlm.nih.gov/pubmed/19277402
  4. Bates SM, Jaeschke R, Stevens SM et al Diagnosis of DVT: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e351S-418S PMID: https://www.ncbi.nlm.nih.gov/pubmed/22315267 (corresponding NGC guideline withdrawn Dec 2017)
  5. 5.0 5.1 5.2 Rodger MA et al Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. The Lancet, Early Online Publication, 25 July 2014 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25066248 <Internet> http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2960793-5/abstract
  6. 6.0 6.1 6.2 6.3 6.4 6.5 Greer IA Pregnancy Complicated by Venous Thrombosis. N Engl J Med 2015; 373:540-547. August 6, 2015 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/26244307 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMcp1407434
  7. James AH. Prevention and treatment of venous thromboembolism in pregnancy. Clin Obstet Gynecol. 2012 Sep;55(3):774-87 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22828110
  8. Bates SM, Greer IA, Middeldorp S et al VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb;141(2 Suppl):e691S-736S. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22315276 (corresponding NGC guideline withdrawn Dec 2017)
  9. 9.0 9.1 9.2 D'Alton ME, Friedman AM, Smiley RM et al National Partnership for Maternal Safety: Consensus Bundle on Venous Thromboembolism. Obstet Gynecol. 2016 Oct;128(4):688-98. PMID: https://www.ncbi.nlm.nih.gov/pubmed/27607857
  10. 10.0 10.1 10.2 10.3 Croles FN, Nasserinejad K, Duvekot JJ et al Pregnancy, thrombophilia, and the risk of a first venous thrombosis: Systematic review and bayesian meta-analysis. BMJ 2017 Oct 26; 359:j4452. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29074563 Free PMC Article
  11. 11.0 11.1 11.2 11.3 NEJM Knowledge+ Hematology
    Marik PE, Plante LA. Venous thromboembolic disease and pregnancy. N Engl J Med. 2008 Nov 6;359(19):2025-33. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18987370 Review. No abstract available. https://www.nejm.org/doi/pdf/10.1056/NEJMra0707993