thrombin inhibitor

Indications

• anticoagulation

Adverse effects

• hepatotoxicity (ximelagatran)

Overdose

• activated prothrombin concentrate complex 50-100 units/kg IV

• drug adverse effects of antithrombotic agent(s)

Mechanism of action

• inhibition of thrombin

More general terms

• enzyme inhibitor
• pharmaceutical anticoagulant

More specific terms

• argatroban (Novastan)
• dabigatran (Pradaxa)
• desirudin (Iprivask)
• lepirudin; hirudin (Refludan)
• vorapaxar (Zontivity)
• ximelagatran (Exanta)

Additional terms

• thrombin; coagulation factor IIa