secretory diarrhea

Etiology

• pharmaceuticals
  • NSAIDs, colchicine
• endocrine neoplasms
  • carcinoid, gastrinoma, VIPoma
• small intestinal bacterial overgrowth
• bile acid malaborption
  • short bowel syndrome
• villous adenoma

Clinical manifestations

• watery nocturnal bowel movements
• large volume
• unchanged by fasting
• dehyration

Laboratory

• stool osmolality < 340 mosm/kg
• serum elctrolyte disturbances
  • serum sodium: hyponatremia, serum potassium: hypokalemia

Diagnostic procedures

• colonoscopy to evaluate for villous adenoma

More general terms

• diarrhea

More specific terms

• congenital chloride diarrhea
• hereditary diarrhea type 2
• hereditary diarrhea type 3
• hereditary diarrhea type 4