lactate dehydrogenase (LDH) electrophoresis; lactate dehydrogenase isozymes in serum/plasma

Indications

• obsolete method of assessing recent myocardial infarction
  • largely replaced by troponin I in serum

Clinical significance

• increase in LD-1 & LD-2 (anodic isozyme pattern)
  • hemolysis
  • ineffective erythropoiesis
  • renal infarction
  • germ cell tumors
  • myocardial infarction
  • muscular dysrophy
• increase in LD-3 (rare) (midzone pattern)
  • infectious mononucleosis
  • disseminated intravascular coagulation (DIC)
  • platelet destruction
  • splenic necrosis
  • manlignancy
• increase in LD-5 (cathodic isozyme pattern)
  • hepatic damage
    • most frequently from congestive heart failure in hospitalized patients
  • skeletal muscle injury
  • prostate carcinoma
  • malignancy

Notes

• LD-5 1/2life: 10 hours
• LD-1 1/2 life: 100 hours

More general terms

• electrophoresis
• clinical chemistry test

Additional terms

• lactate dehydrogenase (LDH) in serum

Components

• lactate dehydrogenase 5/lactate dehydrogenase total in serum/plasma
• lactate dehydrogenase 4/lactate dehydrogenase total in serum/plasma
• lactate dehydrogenase 3/lactate dehydrogenase total in serum/plasma
• lactate dehydrogenase 1/lactate dehydrogenase 2 in serum/plasma
• lactate dehydrogenase 2/lactate dehydrogenase total in serum/plasma
• lactate dehydrogenase 1/lactate dehydrogenase total in serum/plasma
• lactate dehydrogenase 1 in serum/plasma
• lactate dehydrogenase 2 in serum/plasma
• lactate dehydrogenase 3 in serum/plasma
• lactate dehydrogenase 4 in serum/plasma
• lactate dehydrogenase 5 in serum/plasma