macroglossia

From Aaushi

Jump to navigation Jump to search

^[1]^[2]^[3]

Introduction

Englargement or hypertrophy of the tongue.

Etiology

most common
- amyloidosis especially from multiple myeloma
- congenital hypothyroidism
- genetic syndromes
  - Beckwith-Wiedemann syndrome
  - immunodeficiency, centromere instability & facial anomalies syndrome
- acromegaly
- Hurler syndrome
congenital
- idiopathic muscle hypertrophy
- gland hyperplasia
- hemangioma
- lymphangioma
- Down syndrome
- Beckwith-Wiedemann syndrome
- Behmel syndrome
- lingual thyroid
- gargoylism
- transient neonatal diabetes mellitus
- trisomy 22
- Laband syndrome
- lethal dwarfism of Blomstrand
- mucopolysaccharidoses
- skeletal dysplasia of Urbach
- Tollner syndrome
- microcephaly & hamartoma of Wiedemann
- ganglioside storage disease type 1
acquired
- metabolic/endocrine
  - hypothyroidism, cretinism
  - diabetes mellitus
inflammatory/infectious
systemic
- uremia
- Myxedema
- generalized hypertrophy
- acromegaly
- neurofibromatosis
- iatrogenic macroglossia
traumatic
- surgery
- hemorrhage
- direct trauma (eg, biting)
- intubation injury
- radiation therapy
neoplastic
infiltrative
- amyloidosis
  - light-chain amyloidosis^[3] (image)
- sarcoidosis

Epidemiology

rare

Differential diagnosis

pseudomacroglossia

More general terms

References

↑ Wikepedia: macroglossia http://en.wikipedia.org/wiki/Macroglossia
↑ Thrasher ED and Allen GC Macroglossia eMedicine http://emedicine.medscape.com/article/873658-overview
↑ ^3.0 ^3.1 Alves J, Marto N. Macroglossia in Light-Chain Amyloidosis. N Engl J Med 2018; 378:2321. June 14, 2018. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29897852 https://www.nejm.org/doi/full/10.1056/NEJMicm1716472

Retrieved from "https://aaushi.info/w/index.php?title=A319929&oldid=1172432"

↑ Back to top