hemangioma (strawberry nevus)

Epidemiology

• most common tumors of infancy
• occur in ~10/% of all births

Pathology

• benign vascular lesions enlarge by hyperplasia of endothelial cells & attendant pericytes
• spontaneously involution leaves loose fibrofatty tissue

Genetics

• juvenile hemangioam associated with defects in FLT4

Clinical manifestations

• lesions typically appear a few months after birth
• lesions enlarge rapidly during the first year of life
• spontaneously involution over a period of years

Complications

• hypopigmentation
• skin atrophy

Management

• complete resolution in 1 year common (42-44%)
• pulsed laser treatment NO better than observation
• topical imiquimod may be of benefit for superficial hemangiomas
• oral propranolol 3 mg/kg/day for 6 months is safe & effective
  • propranolol resistance is rare

More general terms

• vascular tissue neoplasm; angioma
• benign neoplasm

More specific terms

• cavernous hemangioma (cavernoma, capillary venous lymphatic malformation, CVL, nevus cavernosus, vascular erectile tumor)
• cutaneous hemangioma
• epithelioid hemangioma; angiolymphoid hyperplasia with eosinophilia
• hepatic hemangioma
• venous lake