vascular endothelial growth factor receptor 3; VEGFR-3; tyrosine-protein kinase receptor FLT4 (FLT4)

Function

• receptor for VEGFC
• has a tyrosine-protein kinase activity

Structure

• belongs to the protein kinase superfamily, Tyr protein kinase family, CSF-1/PDGF receptor subfamily
• contains 7 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 protein kinase domain

Compartment

membrane

Expression

• placenta, lung, heart, & kidney
• does not seem to be expressed in pancreas & brain

Pathology

• defects in FLT4 are the cause of lymphedema hereditary type-1
• defects in FLT4 are found in juvenile hemangioma

More general terms

• vascular endothelial growth factor [VEGF] receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2324
• OMIM: https://mirror.omim.org/entry/136352
• OMIM: https://mirror.omim.org/entry/153100
• UniProt: http://www.uniprot.org/uniprot/P35916.html