neuropeptide Y receptor type 6; NPY6-R; NPY Y1-like receptor; pancreatic polypeptide receptor 2; PP2 (NPY6R, NPY1RL, Y2B)

Function

• when expressed, unable to bind pancreatic polypeptide, neuropeptide Y, or peptide YY, suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

membrane (putative)

Expression

• expressed in heart, skeletal muscle, gastrointestinal tissues, spleen, brain & adrenal glands

Notes

• could be the product of a pseudogene
• may be expressed pseudogene containing a premature stop codon & encoding a non-functional truncated protein missing the last transmembrane domain
• a single base pair deletion relative to the mouse ortholog, results in a truncated protein lacking the 7th transmembrane domain

More general terms

• neuropeptide Y receptor

Database

• OMIM: https://mirror.omim.org/entry/601770
• UniProt: http://www.uniprot.org/uniprot/Q99463.html