pancreatic polypeptide; pancreatic hormone; Obinepitide (PPY, PNP, PP)

Function

• all ingested nutrients stimulate pancreatic polypeptide release
• protein is the most potent food simulus
• release is mediated by vagal stimulation

Structure

belongs to the NPY family

Compartment

secreted

Expression

• synthesized in pancreatic islets of Langerhans

Pathology

• may be cause of watery diarrhea in patients with islet cell tumors

Pharmacology

• Obinepitide is under clinical trial by 7TM pharma to be used for treatment of obesity
• Obinepitide is derived from pancreatic hormone

More general terms

• pancreatic hormone
• neuropeptide

Additional terms

• pancreatic polypeptide in plasma

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5539
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5539
• OMIM: https://mirror.omim.org/entry/167780
• UniProt: http://www.uniprot.org/uniprot/P01298.html