zinc finger protein 161 homolog; Zfp-161; zinc finger protein 5; HZF5; zinc finger & BTB domain-containing protein 14 (ZFP161, ZBTB14)

Function

• transcriptional repressor of c-Myc & thymidine kinase promoters (putative)
• transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'

Structure

• the BTB/POZ domain seems to direct the protein to discrete regions in the nucleus
• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 1 BTB/POZ domain
• contains 5 C2H2-type Zn+2 fingers

Compartment

nucleus

More general terms

• transcriptional silencer (transcriptional repressor)
• DNA-binding protein
• C2H2 type zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7541
• OMIM: https://mirror.omim.org/entry/602126
• UniProt: http://www.uniprot.org/uniprot/O43829.html