transforming growth factor-beta receptor-associated protein 1; TGF-beta receptor-associated protein 1; TRAP-1; TRAP1 (TGFBRAP1)

Function

• plays a role in the TGF-beta/activin signaling pathway
• associates with inactive heteromeric TGF-beta & activin receptor complexes, mainly through the type II receptor, & is released upon activation of signaling
• may recruit SMAD4 to the vicinity of the receptor complex & facilitate its interaction with receptor-regulated smads, such as SMAD2
• interacts with TGFBR2 & ACVR2B; in the absence of ligand stimulation
• interacts with TGFBR1, ACVRL1, BMPR1A & ACVR1B; in the absence of ligand stimulation
• interacts with SMAD4; the interaction seems to be mutually exclusive with the interaction of SMAD4 & phosphorylated SMAD2
• may interact with ALOX5

Structure

belongs to the TRAP1 family

Compartment

• cytoplasm
• colocalizes with TGF-beta receptors in the absence of signaling

More general terms

• receptor

Additional terms

• tgf beta receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9392
• UniProt: http://www.uniprot.org/uniprot/Q8WUH2.html