5-lipoxygenase (arachidonate-5-lipoxygenase, ALOX5)

Function

• catalyzes 1st & 2nd steps of leukotriene synthesis
• may play a role in actin polymerization
• Ser phosphorylation by MAPKAPK2 is stimulated by arachidonic acid Cofactors: Fe+2, Ca+2, ATP

Structure

• belongs to the lipoxygenase family
• contains 1 PLAT domain

Compartment

• cytoplasm, peripheral membrane
• Ca+2 binding promotes binding to membranes

More general terms

• lipoxygenase (arachidonate lipoxygenase, ALOX)
• phosphoprotein

Additional terms

• lipoxygenase cascade

Database

• UniProt: http://www.uniprot.org/uniprot/P09917.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:240
• OMIM: https://mirror.omim.org/entry/152390
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=240