heat shock protein 75 kD, mitochondrial; HSP 75; tumor necrosis factor type 1 receptor-associated protein; TRAP-1; TNFR-associated protein 1 (TRAP1, HSP75)

Function

• chaperone that expresses an ATPase activity
• binds to the intracellular domain of TNF receptor 1
• binds to RB1

Structure

belongs to the heat shock protein 90 family

Compartment

mitochondria

Expression

• found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung & placenta

Comparative biology

• TRAP1 knockout mice show less age-related tissue degeneration, obesity, & spontaneous tumor formation & live longer than normal mice

More general terms

• heat shock protein [hsp]-90 family
• receptor
• mitochondrial protein
• phosphoprotein
• shortened longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10131
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10131
• OMIM: https://mirror.omim.org/entry/606219
• UniProt: http://www.uniprot.org/uniprot/Q12931.html