zinc finger & BTB domain-containing protein 7B; Zfp-67; zinc finger protein Th-POK; T-helper-inducing POZ/Krueppel-like factor; Krueppel-related zinc finger protein cKrox; hcKrox; zinc finger & BTB domain-containing protein 15 (ZBTB7B, ZBTB15, ZFP67, ZNF67)

Function

• transcription regulator
• regulates lineage commitment of immature T-cell precursor
• necessary & sufficient for commitment of CD4+ cell lineage
• absence results in CD8+ cell commitment
• transcriptional repressor of collagen COL1A1 & COL1A2 genes
• repressor of fibronectin & possibly other extracellular matrix genes (putative)

Structure

• contains 1 BTB/POZ domain
• contains 4 C2H2-type Zn+2 fingers

Compartment

nucleus

More general terms

• transcription factor (TF)
• Zinc finger & BTB domain containing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7618
• OMIM: https://mirror.omim.org/entry/607646
• UniProt: http://www.uniprot.org/uniprot/O15156.html