Marburg virus

^[1]^[2]^[3]^[4]^[5]

Epidemiology

2 outbreaks in Equatorial Guinea & one in Tanzania in 2023^[4]
outbreak in Kigali, Rwanda September 2024
- between September 27, 2024 & October 7 56 confirmed infections & 12 deaths^[5]
a person is not contagious until symptoms appear
spread through contact (through broken skin or mucous membranes) with blood or other body fluids
- urine, saliva, sweat, feces, vomit, breast milk, amniotic fluid, or semen of a person who is sick with or has died from Marburg virus, with the body fluids of infected animals, or with needles or other fomites that are contaminated with the virus
not spread through airborne transmission^[4]

early supportive care
fluid replacement^[4]
infection control measures
- contact precautions, protective equipment, splash precautions similar to Ebola virus

7 daily intravenous doses of lipid-encapsulated siRNA resulted in 100% survival of primates given a lethal dose of Marburg virus^[3]

↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1066-67
↑ Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
↑ ^3.0 ^3.1 Thi EP, Mire CE, Ursic-Bedoya1 R et al Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA. Sci Transl Med 20 August 2014: Vol. 6, Issue 250, p. 250ra116 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25143366 <Internet> http://stm.sciencemag.org/content/6/250/250ra116.full
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Centers for Disease Control & Prevention (CDC) Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania. Emergency Preparedness & Response CDC Health Alert Network Health Advisory, April 6, 2023 https://emergency.cdc.gov/han/2023/han00489.asp
↑ ^5.0 ^5.1 Panosian Dunavan C Marburg Virus' Latest Eruption. A veteran fighter against hemorrhagic fevers shares candid thoughts. https://www.medpagetoday.com/opinion/parasites-and-plagues/112339