Marburg virus
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Epidemiology
- 2 outbreaks in Equatorial Guinea & one in Tanzania in 2023[4]
- a person is not contagious until symptoms appear
- spread through contact (through broken skin or mucous membranes) with blood or other body fluids
- urine, saliva, sweat, feces, vomit, breast milk, amniotic fluid, or semen of a person who is sick with or has died from Marburg virus, with the body fluids of infected animals, or with needles or other fomites that are contaminated with the virus
- not spread through airborne transmission[4]
Pathology
- etiologic agent of viral hemorrhagic fever
Clinical manifestations
- fever, headache, myagia, arthralgia, fatigue
- loss of appetite, vomiting, bloody diarrhea
- unexplained bleeding
- seizures[4]
Laboratory
Complications
- high nortality rate (23-90%)[4]
Management
- early supportive care
- fluid replacement[4]
- infection control measures
- contact precautions, protective equipment, splash precautions similar to Ebola virus
Comparative biology
- 7 daily intravenous doses of lipid-encapsulated siRNA resulted in 100% survival of primates given a lethal dose of Marburg virus[3]
More general terms
References
- ↑ Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 1066-67
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 15, American College of Physicians, Philadelphia 2009
- ↑ 3.0 3.1 Thi EP, Mire CE, Ursic-Bedoya1 R et al Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA. Sci Transl Med 20 August 2014: Vol. 6, Issue 250, p. 250ra116 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25143366 <Internet> http://stm.sciencemag.org/content/6/250/250ra116.full
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Centers for Disease Control & Prevention (CDC) Marburg Virus Disease Outbreaks in Equatorial Guinea and Tanzania. Emergency Preparedness & Response CDC Health Alert Network Health Advisory, April 6, 2023 https://emergency.cdc.gov/han/2023/han00489.asp