group 2D secretory phospholipase A2; GIID sPLA2; sPLA2-IID; PLA2IID; phosphatidylcholine 2-acylhydrolase 2D; secretory-type PLA, stroma-associated homolog (PLA2G2D, SPLASH)

Function

• PA2 catalyzes the Ca+2-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
• L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than other phospholipids examined

phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate

Cofactor: binds 1 Ca+2 per subunit

Kinetic parameters:

• pH dependence: optimally active at neutral to alkaline pHs with 2 mM Ca+2

Structure

belongs to the phospholipase A2 family

Compartment

secreted (putative)

Expression

broadly expressed

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
• secreted protein
• Ca+2 binding protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26279
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26279
• OMIM: https://mirror.omim.org/entry/605630
• UniProt: http://www.uniprot.org/uniprot/Q9UNK4.html