ebola virus
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Introduction
Pathology
Genetics
a filovirus: linear non-segmented, - strand RNA virus
80 nm in diameter, up to 14,000 nm in length
- glycoprotein GP
- transmembrane protein, receptor binding
- viral access to cells
- directly cytotoxic
- down-regulates integrins
- immunosuppressive?
- secretory glycoprotein
- inhibits neutrophil activation
- dimer disulfide linked, 2 -S-S- inverted orientation
Clinical manifestations
Laboratory
* safety precautions in handling specimens
* Ebola Virus One-Step recalled due in inaccuracy
Management
- atoltivimab/maftivimab/odesivimab-egbn (Inmazeb) for treatment of infection caused by Zaire Ebola virus
More general terms
Additional terms
References
- ↑ Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ UCLA Department of Pathology, Lecture series, Jan 7, 2002
- ↑ Centers for Disease Control and Prevention (CDC) Guidance for U.S. Laboratories for Managing and Testing Routine Clinical Specimens When There is a Concern About Ebola Virus Disease. http://www.cdc.gov/vhf/ebola/healthcare-us/laboratories/safe-specimen-management.html