milrinone (Primacor Corotrope)

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Introduction

Tradenames: Primacor, Corotrope. (milrinone lactate)

Indications

Contraindications

Cautions:

pregnancy category = c

safety in lactation = ?

Dosage

  • load 50 ug/kg bolus IV over 10 min, then infusion 0.375-0.75 ug/kg/min.

Injection: 1 mg/mL (10 mL, 20 mL). Dosage adjustment with renal failure:

creatinine clearance dosage
30 mL//min 0.33 ug/kg/min
5 mL/min 0.20 ug/kg/min

Pharmacokinetics

elimination via kidney

1/2life = 1.8-3.2 hours

Monitor

Adverse effects

* hypotension, especially in patients receiving vasodilators or with volume contraction

Drug interactions

Mechanism of action

More general terms

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Manual of Medical Therapeutics, 28th ed, Ewald & McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 124
  3. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  4. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  5. Deprecated Reference
  6. 6.0 6.1 Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015

Database