cefaclor (Ceclor)
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Introduction
Tradename: Ceclor. 2nd generation cephalosporin.
Indications
- bacterial infection due to susceptible organisms
- respiratory tract infections
- otitis media
- skin infections & infection of skin appendages
- urinary tract infection
- empiric treatment of fever of unknown origin[4]
Dosage
Tabs: 250, 500 mg
Elixir: 125, 187, 250 & 375 mg/5 mL.
Dosage adjustment in renal failure
- administer 50% of dose if creatinine clearance < 50 mL/min
Pharmacokinetics
- moderately dializable: 20-50%
elimination via kidney
elimination by hemodialysis = +/-
Antimicrobial activity
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Moraxella catarrhalis
- Haemophilus influenzae
- Escherichia coli
- Klebsiella species
- Citrobacter species (+/-)
Adverse effects
- not common (1-10%)
- uncommon (< 1%)
- rash, urticaria, pruritus, nausea, eosinophilia, cholestatic jaundice, arthralgia, Stevens-Johnson syndrome, vomiting, increased serum transaminases (mild), hemolytic anemia, neutropenia
- other: serum sickness-like reaction[3]
More general terms
References
- ↑ The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- ↑ Sanford Guide to antimicrobial therapy 1997
- ↑ Jump up to: 3.0 3.1 Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
- ↑ Jump up to: 4.0 4.1 4.2 4.3 Deprecated Reference
- ↑ Department of Veterans Affairs, VA National Formulary
Database
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=40958
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=51038
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=51039
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2609
- PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5282500