carbapenem (thienamycin)
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Epidemiology
- New Delhi metallo-beta-lactamase 1 (NDM-1) encoded on a gene carried by both bacterial chromosomes & plasmids from E coli & Klebsiella pneumonia confers resistance to carbapenems[3] (isolated from patients in India & Pakistan in 2010)
- carbapenem-resistant Klebsiella pneumoniae & other similarly resistant Enterobacteriaceae are resistant to most antimicrobial drugs, & are frequently fatal[2]
Indications
- meropenem is the carbapenem of choice to treat Pseudomonas
Contraindications
- penicillin allergy
- ertapenem does not cover Pseudomonas
Adverse effects
- carbapenem allergy occurs frequently in patients with penicillin allergy
Laboratory
More general terms
More specific terms
- doripenem (Doribax)
- ertapenem (Invanz, Invance)
- imipenem cilastatin (Primaxin)
- meropenem (Merrem)
- tebipenem
Additional terms
References
- ↑ Journal Watch 24(11):90, 2004 Prescott WA Jr, DePestel DD, Ellis JJ, Regal RE. Incidence of carbapenem-associated allergic-type reactions among patients with versus patients without a reported penicillin allergy. Clin Infect Dis. 2004 Apr 15;38(8):1102-7. Epub 2004 Mar 26. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15095214
- ↑ 2.0 2.1 Lledo W et al Guidance for Control of Infections with Carbapenem-Resistant or Carbapenemase-Producing Enterobacteriaceae in Acute Care Facilities MMWR 2009 58(10);256-260 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5810a4.htm
- ↑ 3.0 3.1 Centers for disease Control and Prevention Carbapenem-Resistant Enterobacteriaceae Containing New Delhi Metallo-Beta-Lactamase in Two Patients - Rhode Island, March 2012 MMWR June 22, 2012 / 61(24);446-448 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6124a3.htm
- ↑ Center for Disease Control and Prevention Vital Signs: Carbapenem-Resistant Enterobacteriaceae MMWR Early Release March 5, 2013 / 62;1-6 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm62e0305a1.htm