etomidate (Amidate)

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Introduction

Tradename: Amidate.

Indications

Contraindications

pregnancy category = c

safety in lactation = ?

Dosage

  • induction 0.2-0.6 mg/kg IV over 30-60 seconds
  • may repeat as necessary
  • 10-20 ug/kg/min

Injection: 2 mg/mL (10 mL, 20 mL)

Pharmacokinetics

  • rapidly distributes to body tissue
  • 76% bound to albumin
  • metabolized by liver & in blood
  • eliminated in the urine
  • terminal 1/2life is 2 hours

elimination via liver

1/2life = 2 hours

Adverse effects

Drug interactions

Mechanism of action

More general terms

References

  1. Clinical Guide to Laboratory Tests, 3rd edition, NW Tietz ed, WB Saunders, Philadelphia, 1998
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Jump up to: 4.0 4.1 Tekwani KL et al. A prospective observational study of the effect of etomidate on septic patient mortality and length of stay. Acad Emerg Med 2009 Jan; 16:11 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19055676
  5. Jump up to: 5.0 5.1 Jabre P et al Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: A multicentre randomised controlled trial. Lancet 2009 Jul 1; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19573904 <Internet> http://dx.doi.org/10.1016/S0140-6736(09)60949-1
    Wenzel V and Lindner KH. Best pharmacological practice in prehospital intubation. Lancet 2009 Jul 1; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/19573905 <Internet> http://dx.doi.org/10.1016/S0140-6736(09)61071-0
  6. Jump up to: 6.0 6.1 Physician's First Watch. Feb 7, 2012 Massachusetts Medical Society McPhee LC et al. Single-dose etomidate is not associated with increased mortality in ICU patients with sepsis: Analysis of a large electronic ICU database. Crit Care Med 2013 Jan 9; PMID: https://www.ncbi.nlm.nih.gov/pubmed/23318491

Database