paromomycin; aminosidine (Humatin, Gabbromicina, Gabbrora)

Indications

• gastrointestinal infections
  • adjunctive treatment to stibogluconate (Sb[V]) for visceral leishmaniasis
  • treatment of cryptosporidium in patients with HIV
  • Dientamoeba fragilis
  • treatment of chronic intestinal amebiasis
  • preoperatively used to suppress intestinal flora
  • tapeworm infestations (fish, dog, bovine, porcine)
  • dwarf tapeworm
  • eradication of NH3-forming bacteria in hepatic coma

Dosage

• visceral leishmaniasis
  • 12-15 mg/kg/day IV or IM
• cryptosporidium in patients with HIV
  • 500 to 750 mg PO TID-QID
• Dientamoeba fragilis
  • 25 to 30 mg/kg/day divided TID for 7 days
• tapeworm infestations (fish, dog, bovine, porcine)
  • adult: 1 g every 15 min for 4 doses
  • children: 11 mg/kg every 15 min for 4 doses
• dwarf tapeworm
  • children & adults: 45 mg/kg QD for 5-7 days
• eradication of NH3-forming bacteria in hepatic coma
  • 4 g/day divided BID-QID for 5-6 days

Capsule: 250 mg.

Adverse effects

• not common (1-10%)
  • diarrhea, abdominal cramps, nausea/vomiting, heartburn
• uncommon (< 1%)
  • headache, vertigo, steatorrhea, secondary enterocolitis, exanthema, rash, pruritus, ototoxicity, eosinophilia

More general terms

• aminoglycoside family
• amebicide

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=165580
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4689
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=24176
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=64144
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441375