streptozocin (Zanosar)

Introduction

Tradename: Zanosar.

Indications

• treatment of metastatic islet cell carcinoma of the pancreas
• carcinoid tumor & carcinoid syndrome
• Hodgkin's disease
• palliative treatment of colorectal carcinoma

Contraindications

Caution:

• avoid aspirin
• use electric razor

pregnancy category = x

safety in lactation = -

Dosage

• may be injected by rapid IV push
• dosage adjustment for renal failure
• refrigerate & protect from light
• discard refrigerated reconstituted solutions after 12 hours

Powder for injection: 1 g

Adverse effects

• common (> 10%)
  • nephrotoxicity (25-75%), nausea/vomiting
• less common (1-10%)
  • diarrhea, hypoglycemia, pain at site of injection
• uncommon (< 1%)
  • liver dysfunction, leukopenia, thrombocytopenia, hematologic toxicity
• other
  • may cause permanent sterility
  • may cause birth defects

Drug interactions

• phenytoin
• other potentially nephrotoxic drugs

• drug interaction(s) of antibiotics with warfarin

Test interactions

increases serum K+

More general terms

• antibiotic antineoplastic agent

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=29327
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5299