anaplastic oligodendroglioma

Introduction

oligodendroglioma with anaplastic features, corresponds to WHO grade III Anaplastic oligodendroglioma has more favorable prognosis compared to glioblastoma although histological features may be similar in some cases.

Genetics

Microarray study:

• glioblastoma gene expression: (fold increase)
  • vimentin: 2.55
  • dCMP deaminase: 2.8 - 4.83
  • SH3 domain GRB2-like endophilin B1: 1.8
  • mitogen activated protein kinase 4: 5.57
  • CD74: 1.89
  • dolichyl-diphosphooligosaccharide protein glycosyltransferase: 1.78
  • ras homolog gene family member C: 2.1
  • lipoma HMGIC fusion partner-like 2: 2.41
  • adenylyl cyclase-associated protein: 1.49
• anaplastic oligodendroglioma gene expression: (fold increase)
  • ribosomal protein S13: 2.2
  • breakpoint cluster region (BCR): 2.64
  • angiopoietin-like 2: 3.96
  • ribosomal protein L24: 1.81
  • ribosomal protein S20: 2.03
  • potassium channel, subfamily K member 3 (TASK-1): 2.43
  • eukaryotic translation initiation factor 3, subunit 6: 1.76
  • ATP binding cassette, subfamily C member 8: 2.16
  • phosphodiesterase 8B: 3.4
  • amiloride-sensitive cation channel 2, neuronal: 2.77

More general terms

• malignant glioma
• oligodendroglial neoplasm