K+ channel subfamily K member 3; acid-sensitive K+ channel protein TASK-1; TWIK-related acid-sensitive K+ channel 1; Two pore K+ channel KT3.1 (KCNK3, TASK, TASK1)

Function

• pH-dependent, voltage-insensitive, background K+ channel protein
• rectification direction results from K+ ion concentration on either side of the membrane
• acts as an outward rectifier when external K+ concentration is low
• when external K+ concentration is high, current is inward

Structure

• belongs to the two pore domain K+ channel (TC 1.A.1.8) family

Compartment

membrane (potential)

Expression

• widespread expression in adult
• strongest expression in pancreas & placenta
• lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine & colon

Notes

• inhibited by external acidification
• activated by halothane & isoflurane

More general terms

• K+ channel subfamily K
• glycoprotein
• transmembrane 4 protein

Database

• UniProt: http://www.uniprot.org/uniprot/O14649.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3777
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3777
• OMIM: https://mirror.omim.org/entry/603220