SH3 domain GRB2-like protein B1 (endophilin-B1, Bax-interacting factor 1, Bif-1, SH3GLB1)

Function

• lysophosphatidic acid acyltransferase activity
• activation of caspases & apoptosis
• binds DNM1, HD, AMPH & BIN1
• binds BAX, induction of apoptosis augments BAX binding

Structure

• homodimer & heterodimer with SH3GLB2
• belongs to the endophilin family
• contains 1 BAR domain
• contains 1 SH3 domain

Compartment

• cytoplasm, peripheral membrane, internal membranes

Alternative splicing

named isoforms=2

Expression

• expressed in heart, skeletal muscle, kidney, placenta > brain, colon, thymus, spleen, liver, small intestine, lung, peripheral blood leukocytes Uncertain whether Met-1 or Met-4 is the initiator

More general terms

• acyltransferase
• endophilin family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51100
• UniProt: http://www.uniprot.org/uniprot/Q9Y371.html