interleukin-4 receptor (IL4 receptor)
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Function
- combined IL-4 receptor & IL-13 receptor ?
- activation of IL-4 receptor synergizes with PKC activation in inducing DNA synthesis in B cells
- at least in part conveys signal through JAK3
- IL-4 response with role in promoting Th2 differentiation
- IL4/IL13 responses with role in regulating IgE production &, chemokine & mucus production at sites of allergic inflammmation
- in certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2
- functional IL4 receptor is formed by initial binding of IL4 to IL4R. subsequent recruitment to the complex of the common gamma chain
Structure
- heterodimer of IL-4 receptor alpha & common receptor gamma
More general terms
Additional terms
References
- ↑ Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8048164
- ↑ Klaus GG, Harnett MM. Cross-talk between B cell surface immunoglobulin and interleukin 4 receptors: the role of protein kinase C and Ca2(+)-mediated signals. Eur J Immunol. 1990 Oct;20(10):2301-7. PMID: https://www.ncbi.nlm.nih.gov/pubmed/2173663
- ↑ Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1334470
- ↑ Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8048164
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3566