calcitonin; contains: katacalcin; calcitonin carboxyl-terminal peptide; CCP; PDN-21 (CALC, CALC1)

Function

• inhibits osteoclastic bone resorption
  • effect is largely on trabecular bone, not cortical bone
  • decreases risk of vertebral fractures, not hip fractures
• lowers serum Ca+2 concentrations
  • causes a rapid but short-lived drop in the level of Ca+2 & phosphate in plasma by promoting the incorporation of these ions into bone
• calcitonin also has analgesic properties

Structure

belongs to the calcitonin family

Compartment

secreted

Alternative splicing

• named isoforms=3
• at least one isoform produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• produced in humans primarily by the parafollicular C-cells of the thyroid

Pharmacology

see Cibacalcin (Calcimar, Miacalcin)

Laboratory

• calcitonin measurement
  • calcitonin in lymph node
  • calcitonin in serum
• calcitonin Ag in tissue

More general terms

• secreted protein
• thyroid hormone

More specific terms

• katacalcin
• procalcitonin; contains: calcitonin, katacalcin; calcitonin carboxyl-terminal peptide; CCP; PDN-21 (CALCA, CALC1)
• salmon calcitonin (Cibacalcin, Calcimar, Miacalcin)

Additional terms

• calcitonin in serum
• calcitonin receptor; CT-R (CALCR)
• osteoporosis
• Paget's disease of the bone; osteitis deformans
• procalcitonin in serum (Vidas Brahms PCT Assay)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=796
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:796
• OMIM: https://mirror.omim.org/entry/114130
• UniProt: http://www.uniprot.org/uniprot/P01258.html