calcitonin receptor; CT-R (CALCR)

Function

• receptor for calcitonin
• activity is mediated by G proteins which activate adenylyl cyclase (Gs proteins)
• thought to couple to the Gs protein that is sensitive to cholera toxin
• interacts with GPRASP2

Structure

belongs to the G-protein coupled receptor 2 family

Compartment

cell membrane

Alternative splicing

named isoforms=3

Polymorphism

• genetic variations in CALCR may be correlated with low bone mineral density, osteoporosis

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• calcitonin; contains: katacalcin; calcitonin carboxyl-terminal peptide; CCP; PDN-21 (CALC, CALC1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:799
• OMIM: https://mirror.omim.org/entry/114131
• UniProt: http://www.uniprot.org/uniprot/P30988.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=799