C-type lectin domain family 12 member A (myeloid inhibitory C-type lectin-like receptor, MICL, C-type lectin-like molecule 1, CLL-1, dendritic cell-associated lectin 2, DCAL-2, CLEC12A, CLL1, DCAL2, MICL)

Function

• cell surface receptor
• modulates signaling cascades
• mediates tyrosine phosphorylation of target MAP kinases
• interacts with PTPN6 & PTPN11

Structure

• highly N-glycosylated
• glycosylation varies between cell types
• contains 1 ITIM motif
• phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
• contains 1 C-type lectin domain

Compartment

• cell membrane
• ligand binding leads to internalization

Alternative splicing

named isoforms=5

Expression

• detected in normal myeloid cells & in acute myeloid leukemia cells
• detected in neutrophils, eosinophils, monocytes & dendritic cells
• detected in spleen macrophage-rich red pulp & in lymph node (at protein level)
• detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes & macrophages

Pathology

• down-regulated in activated leukocytes recruited to a site of inflammation

More general terms

• receptor
• glycoprotein
• membrane protein
• C-type lectin superfamily

Database

• UniProt: http://www.uniprot.org/uniprot/Q5QGZ9.html