Jun dimerization protein 2 (JDP2)

Function

• component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins
• involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis & antitumogeneris
• can also function as a repressor by recruiting histone deacetylase 3 (HDAC3) to the promoter region of JUN
• may control transcription via direct regulation of the modification of histones & the assembly of chromatin
• forms homodimer or heterodimer with JUN, JUNB, JUND, CEBPG & ATF2 thereby inhibiting transactivation by JUN, ATF2 & CEBPG (putative)
• binds multiple DNA elements such as cAMP-response element (CRE) & TPA response element (TRE) either as homodimer or heterodimer (putative)
• phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress & anisomycin treatments

Structure

• belongs to the bZIP family, ATF subfamily
• contains 1 bZIP domain

Compartment

nucleus (probable)

More general terms

• DNA-binding protein
• transcription factor (TF)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1229
• OMIM: https://mirror.omim.org/entry/608657
• UniProt: http://www.uniprot.org/uniprot/Q8WYK2.html