jun-B proto-oncogene protein (JUNB)
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Function
- transcription factor
- role in regulating gene activity following the primary growth factor response
- binds to the DNA sequence 5'-TGA[CG]TCA-3'
- binds DNA as an homodimer or as an heterodimer with another member of the jun/fos family
Structure
- belongs to the bZIP family, Jun subfamily
- contains 1 bZIP domain
Compartment
Expression
induced by growth factors
Pathology
- gene deletion or mutations of junB interfering with junB protein function may be associated with psoriasis & psoriatic arthritis[2]
More general terms
Component of
References
- ↑ Chiu R et al Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell 59:979 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2513128
- ↑ 2.0 2.1 Zenz R et al. Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature 2005 Sep 15; 437:369-75. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16163348
- ↑ Herschman HR Extracellular signals, transcriptional responses and cellular specificity TIBS 14:455 1989 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2696174
- ↑ Atlas of genetics & cytogenetics in oncology& haematology http://atlasgeneticsoncology.org/genes/JUNBID178.html
- ↑ UniProt http://www.uniprot.org/uniprot/P17275.html