platelet glycoprotein 1b

Function

• component of platelet vWF receptor GP-Ib-V-IX & thrombin
• participates in the formation of platelet plugs by binding to the A1 domain of von Willebrand factor, which is already bound to the subendothelium
• becomes exposed on the surface of platelets upon activation
• forms complex with glycoprotein IX & glycoprotein V

Structure

• heterodimer composed of GP-1b alpha & GP-1b beta, disulfide linked
• GP-IX is complexed with the GP-1b heterodimer via a non covalent linkage

More general terms

• adhesion receptor
• multisubunit protein

Additional terms

• glycoprotein-Ib-V-IX complex
• platelet
• von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)

Component of

• glycoprotein-Ib-V-IX complex