glycoprotein-Ib-V-IX complex

Function

• receptor for von willebrand factor (vWF) on cell surface of platelets
• receptor for thrombin
• actual binding site is on glycoprotein 1b-alpha
• mediates vWF-dependent platelet adhesion to blood vessels
• adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis

Structure

• subunits:
  • glycoprotein-Ib
    • GP-Ib alpha & GP-Ib beta are disulfide linked
  • glycoprotein-V
  • glycoprotein-IX

Compartment

• plasma membrane of platelets

More general terms

• molecular complex
• adhesion receptor

Additional terms

• von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)