CD42a; platelet glycoprotein IX; GPIX (GP9)

Function

• forms complex with glycoprotein-Ib & glycoprotein-V, the
• the GPIb-V-IX complex functions as the vWF factor receptor
• GP-IX may provide for membrane insertion & orientation of GP-Ib
• GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage

Structure

contains 1 LRR (leucine-rich) repeat

Compartment

membrane

Expression

• platelets
• megakaryocytes

Pathology

• defects in CD42a are associated with Bernard-Soulier syndrome

More general terms

• CD42

Additional terms

• platelet

Component of

• glycoprotein-Ib-V-IX complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2815
• OMIM: https://mirror.omim.org/entry/173515
• OMIM: https://mirror.omim.org/entry/231200
• UniProt: http://www.uniprot.org/uniprot/P14770.html