C-type lectin domain family 4 member C; blood dendritic cell antigen 2; BDCA-2; C-type lectin superfamily member 7; dendritic lectin; CD303 (CLEC4C BDCA2 CLECSF11 CLECSF7 DLEC HECL, UNQ9361/PRO34150)

Function

• role in antigen-capturing
• targets ligand into antigen processing & peptide-loading compartments for presentation to T-cells
• may mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells
• may act as a signaling receptor that activates protein-tyrosine kinases & mobilizes intracellular Ca+2
• does not seem to bind mannose

Structure

• contains 1 C-type lectin domain

Compartment

• membrane; single-pass type 2 membrane protein (probable)

Alternative splicing

named isoforms=2

Expression

• expressed in plasmacytoid dendritic cells
• constitutively expressed in immature monocyte-derived dendritic cells
• significantly down-regulated upon maturation with LPS but not with TNF-alpha

More general terms

• CD antigen
• C-type lectin superfamily

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=170482
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:170482
• OMIM: https://mirror.omim.org/entry/606677
• UniProt: http://www.uniprot.org/uniprot/Q8WTT0.html