tissue factor pathway inhibitor 2; TFPI-2; placental protein 5; PP5 (TFPI2)

Function

• may play a role in regulation of plasmin-mediated matrix remodeling
• inhibits trypsin, plasmin, factor VIIa/tissue factor & weakly factor Xa
• has no effect on thrombin

Structure

• contains 3 BPTI/Kunitz inhibitor domains

Compartment

secreted

Expression

• expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, & maternal serum near term

More general terms

• serine protease inhibitor; serpin
• placental protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7980
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7980
• OMIM: https://mirror.omim.org/entry/600033
• UniProt: http://www.uniprot.org/uniprot/P48307.html