plexin-C1 (virus-encoded semaphorin protein receptor, CD232 antigen, PLXNC1, VESPR)

Compartment

membrane

Expression

expressed in heart, brain, lung, spleen & placenta

Pathology

• receptor for vaccinia virus semaphorin A39R & for herpesvirus Sema protein
• binding of viral semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton & to secretion of IL6 & IL8

More general terms

• glycoprotein
• CD antigen

Database

• OMIM: https://mirror.omim.org/entry/604259
• UniProt: http://www.uniprot.org/uniprot/O60486.html