plexin-C1 (virus-encoded semaphorin protein receptor, CD232 antigen, PLXNC1, VESPR)
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Function
- PLXCN1 acts as a receptor for SEMA7A in the brain
- role in neurogenesis & synaptic plasticity
Compartment
membrane
Expression
expressed in heart, brain, lung, spleen & placenta
Pathology
- receptor for vaccinia virus semaphorin A39R & for herpesvirus Sema protein
- binding of viral semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton & to secretion of IL6 & IL8
- may contribute to frailty through inflammation-related pathways[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O60486.html
- ↑ 2.0 2.1 2.2 Borhan S, An Nguyen LM, Pigeyre M et al Ordinal GWAS analysis of the frailty phenotype identified a novel locus at 12q22 that underscores the role of the neurological and immune systems. NPJ Aging. 2026 Apr 22;12(1):55. PMID: https://pubmed.ncbi.nlm.nih.gov/42020437 PMCID: PMC13103308 Free PMC article. https://www.nature.com/articles/s41514-026-00363-z