semaphorin-7A; semaphorin-L; sema L; semaphorin-K1; sema K1; John-Milton-Hargen human blood group Ag; JMH blood group antigen; CDw108; CD108 (SEMA7A, CD108, SEMAL)

Function

• in monocytes stimulates
  • cytokine production
  • chemotaxis
  • superoxide release
• may have adhesion function;
• may modulate immune response
• may mediate neuronal function

Structure

• belongs to the semaphorin family
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 PSI domain
• contains 1 sema domain

Compartment

• cell membrane; lipid-anchor, GPI-anchor

Expression

• erythrocytes
• lymphoblasts
• lymphocytes (low levels)
• expressed in placenta, testis, ovary, spleen, brain, spinal cord, lung, heart, adrenal gland, lymph nodes, thymus, intestine & kidney

Pathology

• deficiency may be associated with rare form of congenital dyserythropoietic anemia

Laboratory

• JMH Ab in serum/plasma

More general terms

• CD antigen
• semaphorin or semaphorin/collapsin family protein
• glypiated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8482
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8482
• OMIM: https://mirror.omim.org/entry/607961
• UniProt: http://www.uniprot.org/uniprot/O75326.html