CD35, complement component (3b/4b) receptor-1, C3b-1/Epstein Barr Virus [EBV] receptor or C4-binding protein

Function

• C3b receptor on erythrocytes
• circulates with beta-globulin
• same as C4-binding protein & proline-rich protein of chylomicrons
• mediates cellular binding of particles & immune complexes that have activated complement

Structure

• monomer
• belongs to the receptors of complement activation (RCA) family
• contains 30 Sushi (CCP/SCR) domains

Compartment

membrane

Expression

• granulocytes
• macrophages
• B cells
• T cells ~10%
• NK cells
• erythrocytes
• splenic follicular dendritic cells
• eosinophils
• glomerular podocytes
• astrocytes (some)

Polymorphism

• CR1 contains a system of antigens called the Knops blood group system
• polymorphisms within the Knops blood group system are involved in malarial rosetting, a process associated with cerebral malaria
• common Knops system antigens include McCoy (McC) & Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien)
• Sl(a-) phenotype is more common in persons of African descent & may protect against fatal malaria

More general terms

• CD antigen
• complement-3b [C3b] receptor
• virus receptor
• beta globulin
• glycoprotein
• proline-rich protein

Additional terms

• complement C3b

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1378
• OMIM: https://mirror.omim.org/entry/120620
• OMIM: https://mirror.omim.org/entry/607486
• UniProt: http://www.uniprot.org/uniprot/P17927.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1378