villin-1 (VIL1 VIL)

Function

• Ca+2-regulated actin-binding protein

Structure

• monomer
• consists of a large core fragment, the N-terminal portion, & a small headpiece, the C-terminal portion
• the headpiece binds F-actin strongly in both the presence & absence of Ca+2
• belongs to the villin/gelsolin family
• contains 6 gelsolin-like repeats
• contains 1 HP (headpiece) domain

Compartment

cytoplasm, cytoskeleton

Expression

• major component of microvilli of intestinal epithelial cells & kidney proximal tubule cells

More general terms

• villin

Database

• UniProt: http://www.uniprot.org/uniprot/P09327.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7429
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7429
• OMIM: https://mirror.omim.org/entry/193040