CD88; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR (C5AR1, C5AR, C5R1)

Function

• receptor for the chemotactic & inflammatory peptide anaphylatoxin C5a
• couples to G16-alpha, Gi2 & Gi3.
• effector for C5a mediated inflammation
• granulocyte activation
• stimulates chemotaxis, granule enzyme release & superoxide production
• sulfation plays a role in association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal & mobilize Ca+2 in response to a small peptide agonist

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• granulocytes
• monocytes
• dendritic cells
• astrocytes
• microglia

More general terms

• G-protein coupled receptor; serpentine receptor
• complement receptor
• CD antigen
• glycoprotein
• phosphoprotein

Additional terms

• complement C5a

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:728
• OMIM: https://mirror.omim.org/entry/113995
• UniProt: http://www.uniprot.org/uniprot/P21730.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=728